Hyperglycaemia: definition, symptoms, treatment
Hyperglycaemia: definition, symptoms, treatment
If you have recently been diagnosed with diabetes, the word hyperglycaemia may be a source of confusion for you and your loved ones. Causes, symptoms and treatment: this article will help you understand what episodes of hyperglycaemia are and how to prevent them.
What is hyperglycaemia?
Blood glucose, also known as glycaemia, is the amount of glucose (sugar) in the blood. Its level varies throughout the day and night – rising and falling slightly – and is naturally regulated by the body to not exceed certain thresholds in people without diabetes [1,2,6].
When blood glucose is too high, we speak of hyperglycaemia [1,2]. The term hyperglycaemia is derived from the Greek words "hyper" (high/beyond), "glykys" (sweet/sugar) and "haima" (blood) [3].
When hyperglycaemia is recurrent and lasts over time, it is said to be chronic. This occurs when there is not enough insulin (the hormone that lowers blood glucose) in the blood and/or the body's cells become resistant to the action of insulin. As a result, glucose accumulates in the blood, causing blood glucose levels to rise [1,3,4,5,6].
Chronic hyperglycaemia is characteristic of untreated diabetes. In the long term, it can lead to complications such as slow wound healing, retinopathy (eye conditions), neuropathy (nerve damage), and artery, heart and kidney complications [1,2,3,4,6].
What blood glucose level is indicative of diabetic hyperglycaemia?
The International Diabetes Federation (IDF) and the World Health Organization (WHO) consider that diabetes is present if blood glucose levels are 126 mg/dL (7.0 mmol/L) or higher in the fasting state or 200 mg/dL (11.1 mmol/L) or higher at any time of the day in the presence of symptoms of hyperglycaemia or 2 hours after drinking a liquid containing 75 g of glucose [3,4,5,7].
Signs and symptoms of hyperglycaemia
Moderately-high blood glucose does not usually have noticeable symptoms. However, overly-high blood glucose levels can lead to the appearance of the following signs and symptoms:
- Frequent and abundant urination (polyuria);
- Intense thirst (polydipsia);
- Fatigue and drowsiness;
- Weight loss;
- Nausea and dizzy spells [1,2,3].
Treatment of chronic hyperglycaemia
Depending on your type of diabetes, different treatments aimed at “normalising” blood glucose can be put in place with the help of an endocrinologist:
- Following a specific lifestyle (regular physical activity with a healthy, balanced diet)
- Taking one or more hypoglycaemic (glucose-lowering) drugs in the case of type 2 diabetes;
- Administering insulin if you have type 1 diabetes or in the case of type 2 diabetes where medication and lifestyle changes are not sufficient to control your blood glucose levels [3,5,7,8,9].
Sources:
- Institute for Quality and Efficiency in Health Care (IQWiG),Cologne,Germany. Hyperglycemia and hypoglycemia in type 1 diabetes. May 29, 2007; Last Update:June 29, 2017.
- Institute for Quality and Efficiency in Health Care (IQWiG), Cologne, Germany. Hyperglycemia and hypoglycemia in type 2 diabetes. May 29, 2007; Last Update: January 11, 2018 Institute for Quality and Efficiency in Health Care (IQWiG); 2006.
- Mouri MI, Badireddy M. Hyperglycemia. [Updated 2020 Sep 10]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing.
- A. Petersmann et al. Definition, Classification and Diagnosis of Diabetes Mellitus. Exp Clin Endocrinol Diabetes 2019; 127 (Suppl 1): S1–S7. doi: 10.1055/a-1018-9078.
- D. Giugliano. A.Ceriello and K. Espositio. Glucose metabolism and hyperglycemia. Am J Clin Nutr 2008;87(suppl):217S–22S.
- Hantzidiamantis PJ, Lappin SL. Physiology, Glucose. [Updated 2021 Sep 20]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2021 Jan-.
- IDF. Diabetes Atlas. 9th edition. 2019.
- Ceriello A, Colagiuri S. International Diabetes Federation guideline for management of postmeal glucose: a review of recommendations. Diabet Med. 2008 Oct;25(10):1151-6. doi: 10.1111/j.1464-5491.2008.02565.x. PMID: 19046192; PMCID: PMC2701558.
- S.E Inzucchi et al. Management of Hyperglycemia in Type 2 Diabetes: A Patient-Centered Approach. Diabete care, Vol. 35, june 2012. doi : 10.2337/dc12-0413